Advaxis, Incorporated


Based in North Brunswick, New Jersey, Advaxis is developing proprietary Listeria monocytogenes (Lm) cancer vaccines based on technology developed by Dr. Yvonne Paterson, professor of microbiology at the University of Pennsylvania and chairperson of Advaxis’ scientific advisory board. Advaxis is developing attenuated live Lm vaccines that deliver engineered tumor antigens, which stimulate multiple simultaneous immunological mechanisms to fight cancer.

Saturday, March 13, 2010

Advaxis Develops Room Temperature Formulation of ADXS11-001

03/10/10- News Wire

Advaxis, Inc., the live, attenuated Listeria monocytogenes (Listeria) immunotherapy company has developing a long-term, room temperature, storage-stable form of its vaccines. This would replace the current requirement to keep the product frozen at -70o C before use.

Advaxis has been investigating other methods for preserving its live vaccines without the need for freezing. Although live Listeria can be freeze dried, this method is associated with a loss of 90% or more of the bacterial activity. A recent test of a different method, called “foam drying” has delivered a product, which is stable at room temperature. Recovery of almost 100% of the product was observed and excellent biological activity was seen.


“This exciting work can make it possible to distribute our products to every physician’s office without special equipment using a low cost process,” commented Advaxis Chairman/CEO Thomas A. Moore. “It will be key to the licensing and commercialization of all our vaccine technologies.”